THE PAPER SPOT-TEST - A RAPID METHOD FOR QUANTITATING STANNOUS CONCENTRATIONS IN RADIOPHARMACEUTICAL KITS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 22  (5) , 465-467
Abstract
A simplified, semiquantitative test for the determination of stannous tin in pyrophosphate and other tin-containing radiopharmaceuticals, excluding these stabilized with ascorbic acid and MAA [macroaggregated albumin] preparations was developed. The test involves the formation and disappearance of a positive red color complex in the presence of Sn(II) and an acidified porphyrin solution. With this technique, the time of spot disappearance is directly proportional to the Sn(II) concentration spotted. The procedure is easy to use, requiring only a high-intensity light source (30-W light bulb) and a timing device. The test is accurate, reproducible and sensitive to Sn(II) levels as low as 40 .mu.g/ml. As the procedure is rapid (requiring < 5 min), it can easily be incorporated into the routine radiopharmaceutical quality-control program of any nuclear medicine facility.