Salmonella Infections in Patients with the Acquired Immunodeficiency Syndrome

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Abstract
Defects in T-cell function have been seen in patients with the acquired immunodeficiency syndrome (AIDS). Although the cellular immune system plays a key role in host defense against Salmonella, there have been no detailed reports of salmonellosis in patients with AIDS. Experience with salmonella infections in 6 patients is reported. Salmonellosis in these patients was unusually severe, and was characterized by widespread infection, bacteremia and relapse, despite standard antibiotic treatment. Because of the difficulty in eradicating salmonella infection in patients with AIDS, long-term suppressive treatment with antibiotics seems warranted.

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