Screening for biomarkers in plasma from patients with gangrenous and phlegmonous appendicitis using CE and CEC in combination with MS

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Abstract
Today a high degree of “false” appendicitis diagnoses are occurring. In this study, a screening experiment of biomarkers of two different kinds of appendicitis, gangrenous and phlegmonous, were conducted with CE and CEC coupled to MS. Plasma samples were obtained from patients pre‐ and post‐surgery. A large amount of data was generated to be able to compare them, and chemometrics tools were utilized to visualize the differences. Indicative patterns were found for both pre‐ and post‐surgery of the two types of inflammation as well as between them. The divergences were traced back to the MS peaks obtained in the CE‐ and CEC‐MS setups as possible biomarkers for the two forms of appendicitis.