Analytical Performance and Diagnostic Accuracy of Immunometric Assays for the Measurement of Circulating Oxidized LDL

Open Access

1 April 2006

journal article
clinical trial
Published by Oxford University Press (OUP) in Clinical Chemistry

Vol. 52 (4) , 760-764
https://doi.org/10.1373/clinchem.2005.064337

Abstract

Background: Oxidized LDL (ox-LDL) plays an important role in the pathogenesis of coronary heart disease (CHD). Several tests for circulating ox-LDL have been published. We believe it is critical to carefully evaluate these assays because small differences in performance may have profound effects when results are compared; we therefore compared the analytical and clinical performances of 2 assays: one developed in our laboratory and a commercial assay (Mercodia) that uses the same monoclonal antibody (4E6).

Keywords

This publication has 18 references indexed in Scilit:

Oxidized low-density lipoprotein as a predictor of outcome in patients with unstable coronary artery disease
International Journal of Cardiology, 2006
Plasma Oxidized Low-Density Lipoprotein, a Strong Predictor for Acute Coronary Heart Disease Events in Apparently Healthy, Middle-Aged Men From the General Population
Circulation, 2005
The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort
Diabetes, 2004
Association of High Coronary Heart Disease Risk Status With Circulating Oxidized LDL in the Well-Functioning Elderly
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes
Published by Elsevier ,2003
Circulating Oxidized LDL Is Associated With Subclinical Atherosclerosis Development and Inflammatory Cytokines (AIR Study)
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Oxidized LDL and HDL: antagonists in atherothrombosis
The FASEB Journal, 2001
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
JAMA, 2001
Circulating Oxidized Low Density Lipoprotein Levels
Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Cell Biology of Atherosclerosis
Annual Review of Physiology, 1995