Triiodothyronine (T3) increases cisplatin nephrotoxicity in young and adult rats

1 December 1990

journal article
research article
Published by Wiley in Journal of Applied Toxicology

Vol. 10 (6) , 395-399
https://doi.org/10.1002/jat.2550100603

Abstract

The influence of pretreatment with triiodothyronine (T₃) on cisplatin (CP)‐induced nephrotoxicity was investigated in 10‐ and 55‐day‐old rats. Triiodothyronine pretreatment enhanced CP proteinuria in young and adult rats, and increased blood urea nitrogen concentration in 55‐day‐old rats. As T₃ decreased Pt concentrations in renal tisssue, the enhanced nephrotoxicity of CP by T₃ must have another mechanism. Enhanced CP nephrotoxicity is discussed in connection with an increase of glutathione concentration obtained in renal tissue as a consequence of T₃ pretreatment.

Keywords

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