Comparative studies on angiotensins. IV. Structure of snake (Elaphe climocophora) angiotensin.

1 January 1977

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 25 (12) , 3255-3260
https://doi.org/10.1248/cpb.25.3255

Abstract

Three kinds of snake angiotensins were isolated from the incubation product of snake (E. climocophora) kidney extract with homologous plasma. The amino acid sequences were deduced by the dansyl method as follows: Asp-Arg-Val-Tyr-Val-His-Pro-Phe; X-Asx-Arg-Val-Tyr-Val-His-Pro-Phe-Tyr and X-Asx-Arg-Val-Tyr-Val-His-Pro-Phe-Tyr-Leu. Tyrosine in position 9 was different from histidine of mammalian angiotensins or serine of the fowl. Position 5 was valine as in so-called bovine angiotensin.

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