Experiments with “antrycide” in the Sudan and East Africa

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Abstract
Field tests indicate the curative value of single subcut. injns. of 5 mg./kg. of antrycide methylsulfate against Trypanosoma congolense and T. vivax in African cattle. Pro-phylaxis is successfully attained by the use of a mixture in equal parts of antrycide methylsulfate and antrycide chloride, with the chloride being the better prophylactic agent and the methylsulfate serving as a curative agent for any possible sub-clinical infesta-tions already present in the cattle to be protected. Such protection must be renewed every 8 wks. to prevent the "breakthrough" of drug-resistant strains. Apparently T. brucei of horses, donkeys, and dogs can be cured by similar injns. of the methylsulfate fraction. A few antrycide-resistant strains of T. congolense have been isolated, but no such resistant strains of T. vivax or T. brucei have been found. Initial tests indicate that T evansi of camels and T. simiae of swine can also be controlled by the same dosage as for T. congolense, T. vivax, and T. brucei.

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