Three-receptor, clonal expansion model for selection of self-recognition in the thymus
- 1 February 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 283 (5747) , 527-532
- https://doi.org/10.1038/283527a0
Abstract
The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postulate leads to a model explaining ontogenic and evolutionary selection for self recognition, T lymphocyte effector function, the apparent high frequency of alloreactive T cells and immune response gene activity. The model is contrasted with previous explanations of self-recognition phenomena.Keywords
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