Chromosomal aberrations in persons occupationally exposed to annual x-irradiation doses lower than 25 mSv
- 1 March 1992
- journal article
- Published by IOP Publishing in Journal of Radiological Protection
- Vol. 12 (1) , 33-36
- https://doi.org/10.1088/0952-4746/12/1/005
Abstract
The effect of ionising radiation on humans can vary in severity from changes in the haematopoietic system, skin and microcirculation to the occurrence of the symptoms of acute radiation disease. One of the basic indicators of the effects of ionising radiation at the subcellular level is damaged DNA molecular structure which may be caused by direct as well as indirect exposure. The analysis of chromosomal aberrations is assumed to be one of the most sensitive methods capable of detecting changes in the cell genome of the living organism caused by ionising radiation. These changes are evident earlier than some other symptoms. Taking this into account the authors applied the method to determine possible changes in the cell genome of subjects occupationally exposed to x-irradiation. Subjects were restricted to those exposed to annual radiation levels no higher than 25 mSv (half the maximum permissible dose at the time) as determined by regular personal dosimetry monitoring in the previous two years.Keywords
This publication has 5 references indexed in Scilit:
- Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sampleMutation Research/Genetic Toxicology, 1988
- DNA repair kinetics after exposure to X-irradiation and to internal?-rays in CHO cellsRadiation and Environmental Biophysics, 1986
- DNA strand breaks, repair, and survival in x-irradiated mammalian cells.Proceedings of the National Academy of Sciences, 1976
- Sister chromatid exchanges induced by mitomycin C: a new method of detecting DNA damage at chromosomal levelMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Mechanisms of chromosomal aberration production III. Chemicals and ionizing radiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974