Distribution of the stimulatory GTP-binding proteins, Gs and Golf, within olfactory neuroepithelium
- 1 May 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemical Senses
- Vol. 15 (3) , 333-340
- https://doi.org/10.1093/chemse/15.3.333
Abstract
Several lines of evidence suggest that, for certain odorants, olfactory signal transduction may be mediated by a stimulatory G-protein coupled adenylate cyclase cascade. Two stimulatory G-proteins, G olf and G s , are expressed in olfactory tissue. To evaluate their relative contributions to the process of odorant signal transduction, specific antisera were used to determine the distribution and relative abundance of G olfα and G sα in rat olfactory neuroepithelium and olfactory sensory cilia. These analyses demonstrate that (1) Golf is far more abundant than G s in olfactory neuroepithelium and (2) G olf is essentially the only stimulatory G-protein present in olfactory sensory cilia.This publication has 6 references indexed in Scilit:
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