PLASMA KINETICS OF SMALL MOLECULES DURING AND AFTER HEMOFILTRATION - DECREASE IN HEMOFILTRATION EFFICIENCY RELATED TO INCREASE IN ULTRAFILTRATION RATE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 19  (4) , 193-200
Abstract
The influence of delay in mass transfer on the real efficiency of hemofiltration sessions (HF) was studied in 7 patients during HF at a moderate ultrafiltration rate (UF rate = 100 ml/min) and at a high UF rate (UF rate = 200 ml/min). Real efficiency was expressed as effective clearance (KE) and compared to plasma clearance (Kp); KE/Kp was calculated from the kinetics of small molecules during HF and stabilized rebound post-HF. Rebound in urea and uric acid plasma levels stabilized by 90 min post-HF; increase in the UF rate from 100 to 200 ml/min was responsible for a decrease in KE/Kp of 4% for urea and 11% for uric acid. Plasma creatinine and P levels had not stabilized by 90 min post-HF; it was impossible to calculate effective clearance. The magnitude of the rebound phenomenon for these 2 molecules was considerably greater than for uric acid. The magnitude of the post-HF rebound for creatinine and P might be associated with delayed diffusion from a bound form in the intracellular space.

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