Unexpected Correlation in the Sensitivity of 19 Herpes Simplex Virus Strains to Types I and II Interferons
- 1 September 1997
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 17 (9) , 537-541
- https://doi.org/10.1089/jir.1997.17.537
Abstract
We compared the sensitivity of 19 herpes simplex virus (HSV) strains to type I (IFN-α and IFN-β) and type II (IFN-γ) human interferons in cultures of human retinal epithelial (K-1034) and lung (HEL) cells. Their sensitivities proved to be well correlated, even though type I and type II IFN have been reported to have different antiviral actions. The correlation was not because IFN-γ stimulated the formation of IFN-β, for an antibody that neutralized IFN-β did not reduce its inhibitory effects. Our results show that each HSV strain has a characteristic and similar sensitivity to type I and type II IFN and suggest some common pathway in the mechanism of their antiviral actions.Keywords
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