Translational repression as a conserved mechanism for the regulation of embryonic polarity
- 1 October 1994
- Vol. 16 (10) , 709-711
- https://doi.org/10.1002/bies.950161003
Abstract
The mechanisms used to establish embryonic polarity are still largely unknown. A recent paper(1) describes the expression pattern of the gene glp‐1, which is required for induction events during development of the nematode Caenorhabditis elegans. Although glp‐1 RNA is found throughout the early embryo, Glp‐1 protein is only expressed in anterior cells. This negative translational regulation in posterior cells is shown to be mediated through sequences in the glp‐1 3′ untranslated region (3′UTR). Thus in nematodes, as in Drosophila, translational repression is one mechanism used to establish the embryonic anterior‐posterior axis.Keywords
This publication has 32 references indexed in Scilit:
- Translational regulation of nanos by RNA localizationNature, 1994
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993
- The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryosCell, 1993
- Localization of nanos RNA controls embryonic polarityCell, 1992
- The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryosCell, 1992
- Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cellsCell, 1992
- The origin of pattern and polarity in the Drosophila embryoCell, 1992
- RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanosCell, 1991
- A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryoNature, 1990
- Identification of genes required for cytoplasmic localization in early C. elegans embryosCell, 1988