HUMAN METABOLISM OF CAFFEINE TO THEOPHYLLINE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 13  (2) , 185-192
Abstract
Theophylline peak plasma concentration of over 170 ng/ml average was observed when 300 mg of caffeine, equivalent to 2-3 cups of coffee, was administered to humans. This peak level was not observed until at least 7 h post administration. Accumulation of caffeine, with its subsequent metabolism to theophylline, in patients who consume average quantities of caffeine-containing beverages relative to those patients who avoid such drinks could interfere with bioavailability studies in normal volunteers. However, it may account for only a small portion of the variable clinical effects associated with aminophylline administration.

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