EFFECT OF ANTIOXIDANT (4-METHIL-2,6-DITRETBUTHYLPHENOL) ON MITOTIC DIVISION OF MOUSE-LIVER CELLS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 19  (3) , 329-333
Abstract
The highest increase in the mitotic index (MI) of reticuloendothelial cells [from mice] observed after antioxidant [4-methyl-2,6-di-tert-butylphenol] treatment coincided in time with the maximal MI values of these cells in the untreated animals. The maximal increase of MI in hepatocytes took place when the minimal value of Mi was registered in cells of the control animals. A significant increase in MI occurred both in hepatocytes and reticuloendothelial cells within the first 2 h after antioxidant injection, but at this very time a more evident stimulation was observed for the hepatocytes. Antioxidant doses stimulating cell division produce similar effect on reticuloendothelial cells and hepatocytes, as do steroids and steroid hormones.

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