Bone metastases and bone pain in breast cancer. Are they closely associated?

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Abstract
Patients [190] with breast cancer were prospectively evaluated for bone pain and had Tc 99m-methylene diphosphonate bone scintigraphy for bone metastases. Of the 66 patients showing evidence for bone metastases, 21 (32%) did not have bone pain. There were 155 sites of skeletal metastases, but pain was found in only 50 sites. The age of the patient or involvement of weight-bearing bones did not affect the association between bone metastases and pain. The need for periodic bone scintigraphy, even when the clinical state does not seem to warrant it, is discussed.

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