While hemangioma is a common tumor of infancy, disseminated hemangiomatosis of the newborn is a rare occurrence. Deelman1wrote of a newborn with 200 small hemangiomata of the skin that were associated with visceral vascular lesions. Lunsford2observed an infant who had 834 small papular angiomata six days after birth; the lesions involuted slowly with time. In 1960, Riley and Smith3reported four individuals from one family who had multiple hemangiomata and macrocephaly. We have observed two patients with small multiple angiomata of the skin who had evidence of involvement of the central nervous system. We consider that the cutaneous lesion is unusual and shall present case reports of these two patients as illustrative of widespread hemangiomatosis of the skin but noteworthy in view of involvement of the central nervous system. Report of Cases Case1.—A white male infant was born at full term on July 12,