Effect of Carnitine on Lipolysis in Subcutaneous Adipose Tissue of Newborns
- 1 January 1974
- journal article
- Published by S. Karger AG in Neonatology
- Vol. 25 (1-2) , 85-94
- https://doi.org/10.1159/000240681
Abstract
L-Carnitine enhanced glycerol release from new born subcutaneous adipose tissue fragments with or without simultaneous stimulation with isoproterenol (10––5 M) or theophylline (10––3 M) (p ≤ 0.05). Deoxycarnitine (2.5 mM) decreased lipolysis under similar conditions (p ≤ 0.05). The optimal concentration of L-carnitine (10––3 M) was determined by a dose response curve in isolated neonatal adipocytes. In adult subcutaneous adipose tissue fragments, L-carnitine increased lipolysis only in the presence of the β-stimulator isoproterenol (10––5 M) (p ≤ 0.05), while deoxycarnitine had no effect.Keywords
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