ANGIOGRAPHIC OBSERVATIONS ON THE TREATMENT OF PULMONARY THROMBOEMBOLISM WITH UROKINASE

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Abstract
Urokinase, an activator of the proenzyme of the fibrinolytic system, has been injected by catheter into the pulmonary circulation in a single dose of 15,000 CTA units per kg. of body weight in the treatment of 10 patients with recent, and in most cases, massive pulmonary thromboembolism. Other investigators in most instances have used about 2.5 times as much urokinase per patient administered through a continuous intravenous infusion over an 8 hour period.The evolution of the thromboemboli was followed by serial angiograms at daily intervals for 2 to 3 days and again at 6 to 9 days, by monitoring of the pulmonary arterial pressures, flows and resistances, the clinical course, and, in most instances, lung scans.The results were classified as good to excellent in 4 cases, partial or incomplete in 4, and minimal in 1. Observations in 1 patient were incomplete.

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