Heparan Sulfate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus

Abstract
The purposes of this communication are (i) to summarize the evidence that heparan sulfate moieties of proteoglycans serve as cell surface receptors for herpes simplex virus (HSV) and (ii) to describe the heparin-binding viral glycoproteins that mediate the binding of virus to cells. These topics are discussed in the context of the molecular interactions required for entry of HSV into cells and, also, the pathology of HSV infections.