Disruption of imprinting caused by deletion of the H19 gene region in mice
- 4 May 1995
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 375 (6526) , 34-39
- https://doi.org/10.1038/375034a0
Abstract
The imprinted H19 gene, which encodes an untranslated RNA, lies at the end of a cluster of imprinted genes in the mouse. Imprinting of the insulin-2 and insulin-like growth factor 2 genes, which lie about 100 kilobases upstream of H19, can be disrupted by maternal inheritance of a targeted deletion of the H19 gene and its flanking sequence. Animals inheriting the H19 mutation from their mothers are 27% heavier than those inheriting it from their fathers. Paternal inheritance of the disruption has no effect, which presumably reflects the normally silent state of the paternal gene. The somatic overgrowth of heterozygotes for the maternal deletion is attributed to a gain of function of insulin-like growth factor 2, rather than a loss of function of H19.Keywords
This publication has 52 references indexed in Scilit:
- Genomic imprinting of Mash2, a mouse gene required for trophoblast developmentNature Genetics, 1995
- Essential role of Mash-2 in extraembryonic developmentNature, 1994
- Parental imprinting of autosomal mammalian genesCurrent Opinion in Genetics & Development, 1994
- Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprintingNature Genetics, 1994
- Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Genes & Development, 1993
- Parental imprinting of the mouse H19 geneNature, 1991
- Parental imprinting of the mouse insulin-like growth factor II geneCell, 1991
- Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursorsNature, 1990
- The product of the H19 gene may function as an RNA.Molecular and Cellular Biology, 1990
- DIFFERENTIAL IMPRINTING AND EXPRESSION OF MATERNAL AND PATERNAL GENOMESAnnual Review of Genetics, 1988