Further Studies on the Adjuvant Effect of Silica on IgE Antibody Production in Mice
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 59 (4) , 427-431
- https://doi.org/10.1159/000232290
Abstract
The effects of amorphous silica (Aerosil) and of aluminium hydroxide on anti-DNP IgE antibody production were studied in Swiss mice preimmunized with Ascaris protein and then challenged 7 days later with DNP-ASC. Aerosil exerted an adjuvant effect especially when it was injected together with the DNP-ASC conjugate. Al(OH)3 had a weaker adjuvant effect than that produced by Aerosil and only when it was injected with the DNP-ASC conjugate. Al(OH)3 given with Ascaris extract 7 days before complete antigen had an inhibitory effect on the anti-DNP IgE antibody production.Keywords
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