Small (≤ 2 cm) Hepatic Lesions in Colorectal Cancer Patients: Detection and Characterization on Mangafodipir Trisodium–Enhanced MRI

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Abstract
OBJECTIVE. The purpose of this study was to evaluate whether mangafodipir trisodium (MnDPDP)–enhanced MRI improves the detection and characterization of small (≤ 2 cm) hepatic lesions in patients with colorectal carcinoma, compared with helical CT.SUBJECTS AND METHODS. Sixty-nine patients who had or were suspected of having focal liver lesions underwent helical CT and MnDPDP-enhanced MRI and constituted the study population. Two experienced radiologists independently reviewed CT and MR images for the number of hepatic lesions seen and whether the lesion appeared to be benign or metastatic; their interpretations were correlated with the reference diagnoses, including histopathologic diagnoses in 35 patients. The lesions were categorized as small (≤ 2.0 cm in diameter) or large (> 2.0 cm). The differences between MnDPDP-enhanced MRI and helical CT with regard to the detection rates for hepatic lesions and metastases and with regard to the false-positive rates for hepatic metastases were analyzed using the M...