ISOLATION AND STRUCTURAL STUDIES OF COPRINE, DISULFIRAM-LIKE CONSTITUENT OF COPRINUS-ATRAMENTARIUS

  • 1 January 1975
    • journal article
    • research article
    • Vol. 38  (6) , 489-496
Abstract
Coprine, the constituent of the mushroom C. atramentarius Fr. responsible for its disulfiram-like activity, was isolated. Chemical and spectral data indicate that the compound is N5-(1-hydroxycyclopropyl)glutamine. Although coprine produced hyperaldehydemia in mice following ethanol ingestion, the compound was not an inhibitor of mouse liver aldehyde dehydrogenase in vitro.