IMMUNOLOGICAL ASPECTS OF CEREBRAL-LESIONS IN MURINE MALARIA
- 1 January 1989
- journal article
- research article
- Vol. 75 (1) , 136-140
Abstract
The majority of male C57B1/Rij mice died infected with Plasmodium berghei early in the second week. Death was closely correlated with collapse of the thermoregulation of the body, with perivascular oedema and petechial haemorrhages in the brain. Mice that did not show a collapse of thermoregulation (temperature drop below 30.degree.C) and survived for more than 2 weeks after infection did not shown haemorrhages. Development of this syndrome (temperature below 30.degree.C; early death; haemorrhages) during infection depended on the presence of the spleen and was prevented by irradiation of the spleen or a timely treatment with dexamethasone, anti-T-cell serum or immune serum.This publication has 13 references indexed in Scilit:
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