ACV Synthetase
- 1 January 1992
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Biotechnology
- Vol. 12 (3) , 245-260
- https://doi.org/10.3109/07388559209069194
Abstract
ACV synthetase (ACVS) is the first enzyme and plays a key role in the biosynthesis of all natural penicillins and cephalosporins. The enzyme is extremely unstable and little had been known about it until recently. This article summarizes the progress in research on this enzyme, including the establishment of a cell-free assay system, stabilization, purification, characterization, and gene cloning. A possible reaction sequence for ACVS catalysis is suggested.Keywords
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