Effect of Prolonged Chlorpromazine Administration on the Sleep of Chronic Schizophrenics
- 1 July 1974
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 31 (1) , 62-66
- https://doi.org/10.1001/archpsyc.1974.01760130044007
Abstract
The sleep of 13 chronic male schizophrenics was studied during a one-month trial of chlorpromazine and compared with one-month placebo periods. Electroencephalographic recordings were made only after the patients had been on chlorpromazine hydrochloride or a placebo for at least three weeks. Sleep latency and awake time were significantly decreased on chlorpromazine while stage II, delta sleep, delta%, nonrapid eye movement (NREM) sleep, REM activity, REM latency, and REM density were significantly increased. There were no significant changes in REM time, REM%, stage II%, and NREM%.Keywords
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