Serum eosinophilotactic activity in eosinophilic fasciitis

Publisher Website
Google Scholar
Abstract
Serum eosinophil chemotactic activity was determined by the Boyden chamber technique in 20 patients with eosinophilic fasciitis. Increased eosinophil chemotactic activity (>125% of background) was found in all 20 patients (mean 297% ± 129), whereas sera of 20 controls with systemic sclerosis and diffuse scleroderma had increased eosinophil chemotactic activity in only 6 (30%) instances (mean 96% ± 47, P<0.001). Although serum eosinophil chemotactic activity decreased over time in all 8 eosinophilic fasciitis patients studied longitudinally, this activity returned to normal in only 3, all of whom received prolonged courses of corticosteroids. Preliminary data suggest the existence of a eosinophilotactic serum factor common to patients with eosinophilic fasciitis.
Funding Information
  • Allergic Diseases Academic Award ((AI-00431))
  • National Institute of Allergy and Infectious Diseases ((AI-17268))
  • United States Public Health Service ((FR-00056))