Citrate in Plasma and Urine During Total Fasting

Publisher Website
Google Scholar
Abstract
Plasma citrate was determined in 12 obese subjects who underwent total fasting for 10 days. Mean plasma citrate concentration rose significantly from 128 before to 205 .mu.mol/l on the 10th day of fasting. Plasma citrate rose continuously during fasting in 7 subjects in whom daily determinations were carried out. The 24 h urinary citrate excretion was followed in 6 subjects. A significant decrease was found from 2.91 mmol/24 h in the prefasting state to 0.25 mmol/24 h at the end of the fast. I.v. glucose tolerance tests [IVGTT] were performed before and on the 10th day of fasting. KIVGTT [rate constant during IVGTT] decreased significantly and was inversely related to plasma citrate concentration on the 10th day of fasting. The results agree with the concept that an increased citrate level of tissues is of regulatory importance for the decreased glucose utilization during fasting in man.

This publication has 18 references indexed in Scilit: