Rearrangements during the synthesis of substituted 1-benzylpyrrolidines and 3-substituted 1-benzylpiperidines
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 938-940
- https://doi.org/10.1039/p19760000938
Abstract
The preparation and interconversion of some 2-substituted 1-benzypyrrolidines and 3-substituted 1-benzyl-piperidines through intermediate aziridines is described. Reduction of a mixture of 2-azidomethyl-1-benzyl-pyrrolidine and 3-azido-1-benzylpiperidine, prepared either from 2-chloromethyl-1-benzylpyrrolidine or 3-chloro-1-benzylpiperidine, afforded a 50 : 50 mixture of 2-aminomethyl-1-benzylpyrrolidine and 3-amino-1-benzyl-piperidine.Keywords
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