A New Sesquiterpene Ester from Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells
- 1 January 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (1) , 108-111
- https://doi.org/10.1021/np9702392
Abstract
In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1β,2β-diacetoxy-6α,9α-bis(benzoyloxy)dihydro-β-agarofuran. Compounds 1 − 3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.Keywords
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