CLINICAL STUDIES WITH TOLMETIN: OPEN STUDY AND A DOUBLE-BLIND CROSS-OVER COMPARISON WITH ASPIRIN IN RHEUMATOID ARTHRITIS
- 1 August 1978
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 17 (3) , 150-154
- https://doi.org/10.1093/rheumatology/17.3.150
Abstract
Twenty out-patients with rheumatoid arthritis took part in a preliminary open study to investigate the use of tolmetin in rheumatoid arthritis; two comparisons were made with indomethacin and the remainder with aspirin. The results were favourable for tolmetin and the number of side-effects was low. The multi-centre double-blind trial which followed studied 40 out-patients and compared aspirin with tolmetin. Improvements were found in grip strength and active joint count, but not in pain score, morning stiffness and proximal interphalangcal joint circumference.Keywords
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