NEUTRALIZATION ANTIBODY-RESPONSES INDUCED BY JAPANESE ENCEPHALITIS-VIRUS VACCINE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 24  (4) , 137-145
Abstract
Single doses of Japanese encephalitis (JE) Nakayama strain vaccine were given to members of a hospital staff and 99 paired-sera were obtained. Neutralization antibody titers were determined against the Nakayama strain and E-50 strain, isolated from wild Culex tritaeniorhynchus using clone C6/36 of Singh''s Aedes albopictus mosquito cell culture. Post-vaccination sera showed a significant neutralizing antibody response against both the Nakayama and E-50 strain. The geometric mean neutralization titers of post-vaccination sera against the Nakayama and E-50 strains were of the same order, although the geometric mean neutralization titer against the Nakayama strain was higher in pre-vaccination sera. The antibody responses against the Nakayama strain and E-50 strain were somewhat different: 7 individuals with pre-vaccination neutralization titers of < 10 showed antibody responses to the Nakayama strain; 3 individuals of the same group did not show any detectable response to the E-50 strain.