Mitogen-activated protein kinases in apoptosis regulation
Top Cited Papers
- 12 April 2004
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 23 (16) , 2838-2849
- https://doi.org/10.1038/sj.onc.1207556
Abstract
Cells are continuously exposed to a variety of environmental stresses and have to decide 'to be or not to be' depending on the types and strength of stress. Among the many signaling pathways that respond to stress, mitogen-activated protein kinase (MAPK) family members are crucial for the maintenance of cells. Three subfamilies of MAPKs have been identified: extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38-MAPKs. It has been originally shown that ERKs are important for cell survival, whereas JNKs and p38-MAPKs were deemed stress responsive and thus involved in apoptosis. However, the regulation of apoptosis by MAPKs is more complex than initially thought and often controversial. In this review, we discuss MAPKs in apoptosis regulation with attention to mouse genetic models and critically point out the multiple roles of MAPKs.Keywords
This publication has 187 references indexed in Scilit:
- Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem CellsPublished by Elsevier ,2003
- Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factorNature Medicine, 2002
- Frizzled Receptors Activate a Novel JNK-Dependent Pathway that May Lead to ApoptosisCurrent Biology, 2002
- Impaired Synergistic Activation of Stress-activated Protein Kinase SAPK/JNK in Mouse Embryonic Stem Cells Lacking SEK1/MKK4Journal of Biological Chemistry, 2001
- βPix-enhanced p38 Activation by Cdc42/Rac/PAK/MKK3/6-mediated PathwayJournal of Biological Chemistry, 2001
- The Hallmarks of CancerCell, 2000
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammationNature, 1997
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling PathwaysScience, 1997
- Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced ApoptosisJournal of Biological Chemistry, 1996
- Primary Structure of BMK1: A New Mammalian MAP KinaseBiochemical and Biophysical Research Communications, 1995