THE EFFECT OF N-CYCLOHEXYL LINOLEAMIDE ON EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

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Abstract
The effect of N-cyclohexyl linoleamide (AC-32) on experimental atherosclerosis in rabbits was investigated in comparison with those of linoleic acid, ethyl linoleate, safflower oil, N-cyclohexyl safflower oil fatty acids amide (AC-32-z) and N-cyclohexyl stearamide (AC-252). The results obtained are summarized as follows: Daily administration of 200 mg or 400 mg of AC-32 markedly suppressed the increase in serum and liver cholesterol levels and inhibited atheromatous changes of intima of aorta. AC-32-z showed a similar effect to AC-32. AC-252 showed serum cholesterol-lowering effect but the effect was less than that of AC-32. Linoleic acid, ethyl linoleate and safflower oil did not show any significant effect on serum cholesterol level and atherosclerosis at dose levels of 200 mg or 400 mg per day per animal. Even at higher doses of safflower oil (800 to 1, 600 mg per day), no significant effect was observed.