SALT-SOLUBLE COLLAGEN IN EXTRACTS OF UTERUS MUSCLE AND IN FOETAL METAMYOSIN

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Abstract
By repeated precipitation with ammonium sulphate at 20% saturation, a fraction x containing up to about 40% of collagen was obtained from extracts of non-pregnant uteri made with buffered 0-5M potassium chloride-2 mM-ATP. The properties of fraction X were studied and a sample of purified salt-soluble collagen was prepared from it. Dilution precipitates made from the pregnant and non-pregnant uteri contained small amounts of salt-soluble collagen about 1-4% in the former and 3-5% in the latter. Preparations of metamyosin from pig and sheep foetal muscle had salt-soluble collagen content 8-14%. The properties of fraction X are discussed in relation to those of adult and foetal metamyosin, contractin and gamma-myosin.