Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy
- 1 November 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (11) , 3963-3965
- https://doi.org/10.1128/aac.00393-06
Abstract
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.Keywords
This publication has 19 references indexed in Scilit:
- Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type StrainInfection and Immunity, 2006
- The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicansInfection and Immunity, 2004
- Fungicidal Activity of Fluconazole against Candida albicans in a Synthetic Vagina-Simulative MediumAntimicrobial Agents and Chemotherapy, 2004
- Current Perspectives on Ophthalmic MycosesClinical Microbiology Reviews, 2003
- Calcineurin Is Essential for Candida albicans Survival in Serum and VirulenceEukaryotic Cell, 2003
- Resistance Mechanisms in Clinical Isolates of Candida albicansAntimicrobial Agents and Chemotherapy, 2002
- Calcineurin is essential for survival during membrane stress in Candida albicansThe EMBO Journal, 2002
- Pharmacotherapy of fungal eye infectionsExpert Opinion on Pharmacotherapy, 2001
- Fungal and Parasitic Infections of the EyeClinical Microbiology Reviews, 2000
- Practice Guidelines for the Treatment of CandidiasisClinical Infectious Diseases, 2000