Nuclear Factor κB Signaling in Atherogenesis
Top Cited Papers
- 1 May 2005
- journal article
- review article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (5) , 904-914
- https://doi.org/10.1161/01.atv.0000160340.72641.87
Abstract
Atherosclerosis is an inflammatory disease, characterized by the accumulation of macrophage-derived foam cells in the vessel wall and accompanied by the production of a wide range of chemokines, cytokines, and growth factors. These factors regulate the turnover and differentiation of immigrating and resident cells, eventually influencing plaque development. One of the key regulators of inflammation is the transcription factor nuclear factor κB (NF-κB), which, for a long time, has been regarded as a proatherogenic factor, mainly because of its regulation of many of the proinflammatory genes linked to atherosclerosis. NF-κB may play an important role in guarding the delicate balance of the atherosclerotic process as a direct regulator of proinflammatory and anti-inflammatory genes and as a regulator of cell survival and proliferation. Here we address recent literature on the function of NF-κB in inflammatory responses and its relation to atherosclerosis.Keywords
This publication has 103 references indexed in Scilit:
- De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signallingNature, 2004
- Overexpression of mutated IκBα inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formationJournal of Vascular Surgery, 2003
- Fibrates down-regulate IL-1–stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB–C/EBP-β complex formationBlood, 2003
- Inflammation in atherosclerosisNature, 2002
- Innate and acquired immunity in atherogenesisNature Medicine, 2002
- 4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent ProteolysisJournal of Biological Chemistry, 1999
- Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κBFEBS Letters, 1998
- IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.Journal of Clinical Investigation, 1998
- Antisense Oligonucleotides to the P65 Subunit of NF-κb Inhibit Human Vascular Smooth Muscle Cell Adherence and Proliferation and Prevent Neointima Formation in Rat Carotid ArteriesBiochemical and Biophysical Research Communications, 1995
- Regulation of M-CSF Expression by M-CSF: Role of Protein Kinase C and Transcription Factor NFkBPathobiology, 1991