Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme
- 1 September 1974
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 141 (3) , 915-917
- https://doi.org/10.1042/bj1410915
Abstract
The hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme has been investigated by using an automated ninhydrin technique. The results show an inverse relationship of hydrolysis rate with size and charge of the peptide, which parallels the inactivation in the pulmonary circulation and offers an explanation for the selectivity of metabolism of these kinins by the lungs.Keywords
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