Role of Endogenous Prostaglandins in Duodenal Alkaline Response to Luminal Hydrochloric Acid or Arachidonic Acid in Conscious Dogs
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 34 (4) , 268-274
- https://doi.org/10.1159/000199340
Abstract
Duodenal secretion of HCO3- and luminal release of PGE2 were measured in conscious dogs. The results show that the HCO3- secretion is closely correlated with the luminal release of PGE2 and that both the HCO3- and the PGE2 outputs increase dose-dependently after topical application of hydrochloric acid or arachidonic acid. Indomethacin reduced basal HCO3- and PGE2 release and prevented their increase in response to hydrochloric acid or arachidonic acid. We conclude that mucosal PGE2 plays an important role in the alkaline secretion from the duodenum.This publication has 2 references indexed in Scilit:
- Gut hormones in stimulation of gastroduodenal alkaline secretion in conscious dogsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1985
- Gastroduodenal alkaline response to acid and taurocholate in conscious dogsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1984