Mechanism ofFusariummycotoxin action in mammary gland
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 4 (1) , 1-8
- https://doi.org/10.1080/15287397809529638
Abstract
The interaction of the Fusarium mycotoxins zearolenone and dihydrozearalanol with specific estrogen binding sites was studied by using cytosol preparations of mammary glands from lactating rats. Both substances inhibited [3H]estradiol‐17β association with its binding site in a competitive fashion. This inhibition was a result principally of an effect on estrogen binding by the 8S species of receptors separated by density gradient centrifugation. These data suggest that the biological action of Fusarium mycotoxins with estrogenic activity is mediated by intracellular estrogen receptors.This publication has 11 references indexed in Scilit:
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