IgG Oligoclonal Bands in Sera of HIV-1 Infected Patients Are Mainly Directed Against HIV-1 Determinants
- 1 May 1990
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 6 (5) , 581-586
- https://doi.org/10.1089/aid.1990.6.581
Abstract
In a series of 60 HIV-1-infected individuals, serum electrofocusing analysis disclosed clonally restricted IgG patterns in 9 patients (15%), most with limited disease progression (stages WR1-WR3). These oligoclonal bands had a very heterogeneous light chain pattern, and most showed specificity for HIV-1 in affinity-driven transfer studies; virus specificity was more clear-cut following adsorption of sera with the relevant antigen. These findings further stress the profound B-cell function derangement in HIV-1 infection; their possible relevance to AIDS-associated lymphoma development is discussed.This publication has 22 references indexed in Scilit:
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