Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors
- 1 February 1991
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 34 (2) , 518-525
- https://doi.org/10.1021/jm00106a006
Abstract
A series of styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles were prepared and found to be dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia cells. Compounds from this series also were found to inhibit the in vivo production of LTB4 when dosed orally in rats. Among these compounds, di-tert-butylphenols 19 and 33 exhibit oral activity in various models of inflammation and, most importantly, are devoid of ulcerogenic potential.Keywords
This publication has 0 references indexed in Scilit: