Polymers for intracellular delivery of nucleic acids

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Abstract
Effective delivery of nucleic acids requires overcoming cellular barriers that would otherwise hinder transport of payload from the extracellular space to the cytoplasm or nucleus of a target cell, and preventing the degradation of the payload. As with many drug-delivery systems, toxicity is an important issue. Rational design of polymers for this purpose, assisted by high-throughput synthesis and screening methods, has had an enormous impact on the field.
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