The Effects of Reference Anthelmintics against Nematospiroides dubius and Oxyurids in Mice Relative to Screening Procedures for New Drugs

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Abstract
Eleven reference anthelmintics were tested against experimental N. dubius (Nematoda: Heligmosomidae) infections and naturally-occurring Syphacia obvelata and Aspiculuris tetraptera infections in mice. Piperazine, pheno-thiazine, tetrachloroethylene, carbon tetrachloride, hexylresorcinol, gentian violet, pyrvinium chloride, dithiazanine iodide and bephenium embonate were active against one or more of the worms; but santonin and oil of chenopodium were not appreciably active. The study was directed toward determining the susceptibility of the 3 test worms to representative reference drugs and the influence of treatment regimen on activity. Inasmuch as neither gavage nor drug-diet treatment proved to be optimal for all drugs and no single worm was optimal for showing activity by all drugs, a combination of these regimens against all 3 worms would seem to be preferred for the adequate screening of new substances.