The Long-term Course of Rapid-Cycling Bipolar Disorder
Open Access
- 1 September 2003
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 60 (9) , 914-920
- https://doi.org/10.1001/archpsyc.60.9.914
Abstract
SEVERAL CONSIDERATIONS give importance to the phenomenon of rapid cycling.1 In accord with the kindling hypothesis evoked to explain it, rapid cycling may reflect a sensitization produced by repeated episodes.2,3 If, as suspected, such sensitization is often an enduring change,3 the prognostic significance of rapid cycling should be long lasting as well. Some follow-up studies have supported this view,4,5 but others have shown rapid cycling to be time limited.6Keywords
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