Transference of Hepatic Coma to Normal Rats from Galactosamine Treated Donors by Reverse Plasma Exchange

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Abstract
It was possible by exchange transfusion to induce the same grade of hepatic coma in normal recipients as had occurred in donors which had previously been treated with D(+) galactosamine hydrochloride (HCl). The exchange transfusion was carried out by carotid arterial and jugular venous cannulation in conscious and unrestrained recipient rats. Thus, the coma inducing compounds generated as a consequence of acute hepatic failure, appear to circulate in the plasma for a considerable time after galactosamine-HCl is cleared and these substances are able to affect the nervous system in the presence of an intact and functioning normal liver.