Pergolide‐induced circling in rats with 6‐hydroxydopamine lesions in the nigrostriatal pathway

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Abstract
In rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal system the behavioral effects of pergolide were compared with those of L-dopa, bromocriptine and lergotrile. In this animal model of parkinsonism, doses of 0.25 mg/kg pergolide (free base) induced vigorous circling for 24 h. Pergolide was more potent than bromocriptine or lergotrile. Pretreatment with .alpha.-methyl-p-tyrosine nearly abolished the effects of bromocriptine, markedly diminished the effects of lergotrile and only partially diminished the effects of pergolide. Apparently, pergolide should be more effective than bromocriptine in the treatment of parkinsonism.

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