Synthesis of 4-Unsubstituted β-LactamsviaDithiocarbonimidates
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (11) , 990-992
- https://doi.org/10.1055/s-1987-28144
Abstract
Cycloaddition of dithiocarbonimidate 1 to the ketene generated in situ from phenoxyacetylchloride in the presence of triethylamine affords the 4-dithioalkyl-2-azetidinones 2 in good yields. Facile conversion of 2 to the 4-unsubstituted ß-lactams 3 can be accomplished by desulfurization with Raney-Nickel. Formation of several interesting products during attempts to bring a carbonyl function at C-4 in 2 has also been described.Keywords
This publication has 0 references indexed in Scilit: