Effect of Nisoldipine on Large Coronary Arteries in situ: Inhibition of Vasoconstriction Induced by Vasopressin

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Abstract
The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had a direct dilatory effect on large coronary arteries in situ and it attenuated the vasoconstriction induced by vasopressin. It shifted the dose-response curve of vasopressin to the right in a noncompetitive manner. Nisoldipine reduced the effect of vasopressin on maximum left ventricular dP/dt, mean aortic pressure, left ventricular end-systolic pressure and heart rate. The results demonstrate that nisoldipine is an effective dilator of large epicardial coronary arteries in situ and inhibits the vasoconstriction induced by vasopressin.